Mechanobiology Lab

Welcome to Han Lab!

We study mechanobiology, particularly on how adherent cells can sense and respond to mechanical stiffness of the extracellular matrix. To investigate this, we have established experimental and computational frameworks for force measurement and adhesion dynamics quantification. We apply these frameworks, with cutting edge computer vision technique, on live-cell microscope images to find out fundamental mechanism underlying mechanosensation in the normal cells and the biomechanical signature in the diseased cells whose signaling has gone awry.


  • July 6, 2021: Nikhil received HRI graduate fellowship of $3000 for the Fall 2021 semester! Congrats! TechToday Coverage

  • Apr 30, 2021: Shaina completed her undergraduate study and graduated. She will continue to work with us as a graduate student. Congratulations and welcome again!

  • Apr 29, 2021: Shaina received an Outstanding Undergraduate Researcher Award, presented to an undergraduate student who has significant research accomplishments, including presentations at conferences or co-authorship of publications. Great job, Shaina!

  • Apr 29, 2021: Katie received a Michael R. Neuman Award, presented to an undergraduate student (sophomore-senior status) who has made contributions in research! Great job, Katie!

  • Mar 29, 2021: Dr. Han's research on nascent adhesion and contribution of talin-vinculin pre-association is finally published in eLife!

  • Dec 19, 2020: Sarah Rowe, a first-year BME undergrad, has joined the lab. Welcome, Sarah!

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